School of Dermatology
    Glossary

    Zinc (topical)

    zink (TOP-ih-kul)

    Definition

    Topical zinc refers to various zinc compounds used in skincare for their anti-inflammatory, antimicrobial, wound-healing, and oil-regulating properties. Different forms of zinc serve different purposes: zinc oxide provides sun protection and soothes irritated skin; zinc pyrithione treats dandruff and seborrheic dermatitis by fighting the Malassezia fungus; zinc sulfate and zinc gluconate have been studied for their ability to reduce acne by inhibiting the growth of C. acnes bacteria and regulating sebum production; and zinc is a key component in calamine lotion for soothing itching and irritation. Zinc also plays a role in wound healing by supporting cell division and immune function. It is found in diaper rash creams, anti-dandruff shampoos, acne treatments, sunscreens, and barrier repair products. Oral zinc supplements have also shown modest benefits for inflammatory acne, though topical application is more commonly recommended in skincare routines.

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